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Abstract |
Subgroup analysis is an exploratory analysis often conducted with the expectation of providing useful information to establish new research hypotheses in medicine. However, use of subgroup analysis is... currently limited, as the number of subgroups is often small, and thus subgroups are selected arbitrarily and typically deviate from subgroups in which the readers of a paper are interested in. In this study, we propose a method for representing the results of subgroup analysis in graphical form by focusing on a comparative clinical study of treatment versus control groups, with survival time as the primary endpoint, and in which subgroups are created by dividing the range of continuous biomarkers. This method unifies and strengthens fragmented data, enabling findings obtained in each subgroup by assuming the Cox proportional hazard model. Moreover, this method renders it possible to obtain information about any subgroup that an outside researcher is interested in.show more
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